The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus
infection has been known for decades. However, most of the studies characterizing this …

Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading
frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral …

Alphaviruses are emerging positive-stranded RNA viruses which replicate and transcribe
their genomes in membranous organelles formed in the cell cytoplasm. The nonstructural …

RNA is a promising nucleic acid technology for both vaccines and therapeutics, and replicon
RNA has gained traction as a next-generation RNA modality. Replicon RNA self-amplifies …

Translation of Sindbis virus subgenomic mRNA (sgmRNA) can occur after inactivation of
eIF2 by phosphorylation in mammalian cells. Several studies have suggested that eIF2 can …

Animal viruses have evolved a variety of strategies to ensure the efficient translation of their
mRNAs. One such strategy is the use of internal ribosome entry site (IRES) elements, which …

During translation initiation, eukaryotic initiation factor 2 (eIF2) delivers the Met-tRNA to the
40S ribosomal subunit to locate the initiation codon (AUGi) of mRNA during the scanning …

Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus and a category B
select agent. Currently, no FDA-approved vaccines or therapeutics are available to treat …

Sindbis virus (SINV) mRNAs contain several motifs that participate in the regulation of their
translation. We have discovered a motif at the 3′ untranslated region (UTR) of viral mRNAs …

Abstract Pateamine A (Pat A) is a natural marine product that interacts specifically with the
translation initiation factor eIF4A leading to the disruption of the eIF4F complex. In the …