Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …

Huntington's disease (HD) is a chronic neurodegenerative disorder caused by an expansion
of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation …

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent
stem cells were used for'omics' analyses to identify mechanisms underlying …

One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

The transcriptional regulation of genes determines the fate of animal cell differentiation and
subsequent organ development. With the recent progress in genome-wide technologies, the …

Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is
thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial …

Huntington disease (HD) is a debilitating, currently incurable disease. Protein aggregation
and metabolic deficits are pathological hallmarks but their link to neurodegeneration and …

Gene expression requires successful communication between enhancer and promoter
regions, whose activities are regulated by a variety of factors and associated with distinct …

Recently, unique areas of transcriptional regulation termed super-enhancers have been
identified and implicated in human disease. Defined by their magnitude of size, transcription …

Correction of mis-splicing events is a growing therapeutic approach for neurological
diseases such as spinal muscular atrophy or neuronal ceroid lipofuscinosis 7, which are …