Recent advances and emerging challenges in the molecular modeling of mechanobiological processes

G Stirnemann - The Journal of Physical Chemistry B, 2022 - ACS Publications
Many biological processes result from the effect of mechanical forces on macromolecular
structures and on their interactions. In particular, the cell shape, motion, and differentiation …

Minireview on fluid manipulation techniques for the synthesis and energy applications of two-dimensional MXenes: advances, challenges, and perspectives

B Richard, SA Thomas, A Reddy M, MR Pallavolu… - Energy & …, 2023 - ACS Publications
A new frontier in the design and applications of useful micro-and nanomaterials was
unlocked by the combination of fluid mechanics with modern engineered technologies …

Regulation of branched versus linear Arp2/3‐generated actin filaments

L Cao, F Ghasemi, M Way, A Jégou… - The EMBO …, 2023 - embopress.org
Activation of the Arp2/3 complex by VCA‐motif‐bearing actin nucleation‐promoting factors
results in the formation of “daughter” actin filaments branching off the sides of pre‐existing …

Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite

T Kotila, H Wioland, M Selvaraj, K Kogan… - Nature …, 2022 - nature.com
Actin polymerization generates forces for cellular processes throughout the eukaryotic
kingdom, but our understanding of the 'ancient'actin turnover machineries is limited. We …

Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly

H Wioland, S Frémont, B Guichard, A Echard… - EMBO …, 2021 - embopress.org
Proteins of the ADF/cofilin family play a central role in the disassembly of actin filaments, and
their activity must be tightly regulated in cells. Recently, the oxidation of actin filaments by …

Formins

DA Valencia, ME Quinlan - Current Biology, 2021 - cell.com
Actin is one of the most abundant proteins in eukaryotes. Discovered in muscle and
described as far back as 1887, actin was first purified in 1942. It plays myriad roles in …

Molecular simulation approaches to probing the effects of mechanical forces in the actin cytoskeleton

F Mukadum, WJP Ccoa… - Cytoskeleton (Hoboken …, 2024 - pmc.ncbi.nlm.nih.gov
Molecular simulation approaches to probing the effects of mechanical forces in the actin
cytoskeleton - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Using microfluidics and fluorescence microscopy to study the assembly dynamics of single actin filaments and bundles

H Wioland, F Ghasemi, J Chikireddy… - Journal of visualized …, 2022 - hal.science
In order to decipher the complex molecular mechanisms that regulate the assembly and
disassembly of actin filaments, it is a great asset to monitor individual reactions live in well …

Microfluidic Biosensor for the In Vitro Electrophysiological Characterization of Actin Bundles

JM Castro, N Azim, N Castaneda… - Journal of …, 2024 - ieeexplore.ieee.org
The essential cytoskeletal protein actin and its functions are paramount for motility,
communication, and locomotive processes in eukaryotic cells. Detection and quantification …

Machine Learning Approaches for Defect Detection in a Microwell-based Medical Device

X Zhao, Y Chen, Y Jiang, A Radenbaugh… - arXiv preprint arXiv …, 2024 - arxiv.org
Microfluidic devices offer numerous advantages in medical applications, including the
capture of single cells in microwell-based platforms for genomic analysis. As the cost of …