The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
RNA repair: hiding in plain sight
S Shuman - Annual Review of Genetics, 2023 - annualreviews.org
Enzymes that phosphorylate, dephosphorylate, and ligate RNA 5′ and 3′ ends were
discovered more than half a century ago and were eventually shown to repair purposeful …
discovered more than half a century ago and were eventually shown to repair purposeful …
Molecular architecture of the human tRNA ligase complex
A Kroupova, F Ackle, I Asanović, S Weitzer… - Elife, 2021 - elifesciences.org
RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein
response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase …
response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase …
Transfer RNA processing–from a structural and disease perspective
S Sekulovski, S Trowitzsch - Biological chemistry, 2022 - degruyter.com
Transfer RNAs (tRNAs) are highly structured non-coding RNAs which play key roles in
translation and cellular homeostasis. tRNAs are initially transcribed as precursor molecules …
translation and cellular homeostasis. tRNAs are initially transcribed as precursor molecules …
The oxidoreductase PYROXD1 uses NAD (P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response
I Asanović, E Strandback, A Kroupova, D Pasajlic… - Molecular Cell, 2021 - cell.com
The tRNA ligase complex (tRNA-LC) splices precursor tRNAs (pre-tRNA), and Xbp1-mRNA
during the unfolded protein response (UPR). In aerobic conditions, a cysteine residue bound …
during the unfolded protein response (UPR). In aerobic conditions, a cysteine residue bound …
Eukaryotic tRNA splicing–one goal, two strategies, many players
JL Gerber, S Köhler, J Peschek - Biological Chemistry, 2022 - degruyter.com
Transfer RNAs (tRNAs) are transcribed as precursor molecules that undergo several
maturation steps before becoming functional for protein synthesis. One such processing …
maturation steps before becoming functional for protein synthesis. One such processing …
Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease
JL Gerber, SI Morales Guzmán, L Worf… - Nature …, 2024 - nature.com
RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein
response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA …
response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA …
Structures of RNA ligase RtcB in complexes with divalent cations and GTP
A Jacewicz, S Dantuluri, S Shuman - RNA, 2022 - rnajournal.cshlp.org
Pyrococcus horikoshii (Pho) RtcB exemplifies a family of binuclear transition metal-and GTP-
dependent RNA ligases that join 3′-phosphate and 5′-OH ends via RtcB-(histidinyl-N) …
dependent RNA ligases that join 3′-phosphate and 5′-OH ends via RtcB-(histidinyl-N) …
Mechanistic basis for oxidative stress protection of the human tRNA ligase complex by the oxidoreductase PYROXD1
L Loeff, A Kroupova, I Asanović, F Boneberg… - bioRxiv, 2023 - biorxiv.org
RTCB is the catalytic subunit of the metazoan tRNA ligase complex (tRNA-LC) that plays
essential roles in tRNA biogenesis and unfolded protein response. The catalytic center of …
essential roles in tRNA biogenesis and unfolded protein response. The catalytic center of …
Insights into the structure and function of the RNA ligase RtcB
To be functional, some RNAs require a processing step involving splicing events. Each
splicing event necessitates an RNA ligation step. RNA ligation is a process that can be …
splicing event necessitates an RNA ligation step. RNA ligation is a process that can be …