Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease, leads to
blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction …

Hemostasis is a sophisticated sequence of events aimed at repairing vessel injury. This
process occurs in combination with angiogenesis, which leads to new blood vessel …

Intracellular G protein-coupled receptors (GPCRs) can be activated by permeant ligands,
which contributes to agonist selectivity. Opioid receptors (ORs) provide a notable example …

Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining
cellular homeostasis. Whereas loss-of-function mutations are generally associated with …

BACKGROUND: The protease thrombin, which elicits multiple physiological and
pathological effects on vascular endothelial cells (ECs), can signal through PARs (protease …

Vascular inflammation causes endothelial barrier disruption and tissue edema. Several
inflammatory mediators act through G protein–coupled receptors (GPCRs), including …

Endothelial dysfunction is associated with vascular disease and results in disruption of
endothelial barrier function and increased sensitivity to apoptosis. Currently, there are …

The protein C pathways : Current Opinion in Hematology The protein C pathways : Current
Opinion in Hematology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet …

Endothelial dysfunction is a hallmark of inflammation and is mediated by inflammatory
factors that signal through G protein–coupled receptors including protease-activated …