The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli,
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …

Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies
associate higher coffee consumption with decreased rates of mortality and decreased rates …

Obesity is associated with cognitive decline. Recent observations in mice propose an
adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in …

Neuroinflammation is tightly associated with onset of depression. The nuclear receptor
related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons is well …

Here, we used RNA capture-seq to identify a large population of lncRNAs that are
expressed in the infralimbic prefrontal cortex of adult male mice in response to fear-related …

Histone acetylation is a key component in the consolidation of long-term fear memories.
Histone acetylation is fueled by acetyl-coenzyme A (acetyl-CoA), and recently, nuclear …

Memory consolidation involves discrete patterns of transcriptional events in the
hippocampus. Despite the emergence of single-cell transcriptomic profiling techniques …

Melatonin (MEL) has been reported to enhance cognitive processes, making it a potential
treatment for cognitive decline. However, the role of MEL's metabolites, N1‐acetyl‐N2 …

The nuclear receptor (NR) superfamily of transcription factors encodes expression of 48
human genes that are important for maintaining cellular homeostasis and in …

Long-lasting changes of synaptic efficacy are largely mediated by activity-induced gene
transcription and are essential for neuronal plasticity and memory. In this scenario …