Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

The eukaryotic genome is organized in the three-dimensional nuclear space in a specific
manner that is both a cause and a consequence of its function. This organization is partly …

Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …

Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …

The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of
genes that control cell identity and repression of genes encoding lineage-specifying …

The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …

Recent studies indicate that even a homogeneous population of cells display heterogeneity
in gene expression and response to environmental stimuli. Although promoter structure …

The mechanisms responsible for the establishment of physical domains in metazoan
chromosomes are poorly understood. Here we find that physical domains in Drosophila …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

The emergence of whole-genome assays has initiated numerous genome-wide studies of
transcription factor localizations at genomic regulatory elements (enhancers, promoters …