Background and Objectives: The development of liver fibrosis as a consequence of
continuous inflammation represents a turning point in the evolution of chronic liver diseases …

Liver fibrosis is a common pathway leading to cirrhosis, which is the final result of injury to
the liver. Accurate assessment of the degree of fibrosis is important clinically, especially …

Second-harmonic generation (SHG) microscopy began to emerge as a high-resolution
optical imaging modality in the late 1990s, about 10 years after two-photon excited …

Accurate detection and quantification of hepatic fibrosis remain essential for assessing the
severity of non-alcoholic fatty liver disease (NAFLD) and its response to therapy in clinical …

Liver disease has been targeted as the fifth most common cause of death worldwide and
tends to steadily rise. In the last three decades, several publications focused on the …

We develop a standardized, fully automated, quantification system for liver fibrosis
assessment using second harmonic generation microscopy and a morphology-based …

The assessment of liver fibrosis provides useful information not only for diagnosis but also
for therapeutic decisions. Although liver biopsy is the current gold standard for fibrosis …

Liver fibrosis assessment by biopsy and conventional staining scores is based on
histopathological criteria. Variations in sample preparation and the use of semi-quantitative …

Objective Inflammation is a biological response of tissue to harmful stimuli. A high-fat diet
was linked to low-grade chronic liver inflammation, which can further lead to more severe …

Liver fibrosis and resultant cirrhosis are amongst the most common outcomes of chronic liver
diseases. Currently, liver transplantation remains the only effective treatment. Thus, a …