Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Reproductive hormones play a crucial role in the growth and maintenance of the
mammalian skeleton. Indeed, the biological significance for this hormonal regulation of …

Osteoporosis, a disease classically attributed to postmenopausal women, is
underappreciated, underdiagnosed, and undertreated in men. However, it is not uncommon …

The role of sex steroids in mammalian maturation is well established. Recently, it has been
increasingly appreciated that sex steroids also play an important role in the propensity of …

Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in primates, which
is predominantly synthesized in the adrenal cortex. A characteristic curve of growth and …

Purpose Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially
decreases with age, which may accelerate osteoporosis. However, the association of …

Objective This study was designed to determine the status of dehydroepiandrosterone
(DHEA) in women with anorexia nervosa (AN) and to assess the efficacy of DHEA …

Despite the well-documented effects of testosterone and its synthetic derivatives—
collectively termed anabolic androgenic steroids (AASs)—on the musculoskeletal system …

Age-associated osteoporosis (AAOP) poses a significant health burden, characterized by
increased fracture risk due to declining bone mass and strength. Effective prevention and …