Highlights•USP7, a widely studied deubiquitinating enzyme, spares substrates from
proteasome degradation.•USP7 interacts with many proteins whose alterations promote …

The ubiquitin-proteasome system (UPS) is an essential protein quality controller for
regulating protein homeostasis and autophagy. Ubiquitination is a protein modification …

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that
erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 …

Viral control of mitochondrial quality and content has emerged as an important mechanism
for counteracting the host response to virus infection. Despite the knowledge of this crucial …

The ubiquitin specific protease, USP7, regulates multiple cellular pathways relevant for
cancer through its ability to bind and sometimes stabilize specific target proteins through …

Human herpesvirus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRFs) that
target cellular IRFs and/or other innate-immune and stress signaling regulators and …

The ubiquitin specific protease 7 (USP7 or HAUSP) is known to regulate a variety of cellular
processes by binding and deubiquitylating specific target proteins. To gain a more …

Merkel cell polyomavirus (MCPyV) is the major cause for Merkel cell carcinoma (MCC), a
rare but highly aggressive skin cancer predominantly found in elderly and …

Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma (KS)-associated
herpesvirus, is involved etiologically in AIDS-associated KS, primary effusion lymphoma …

Deubiquitinase (DUB)‐mediated cleavage of ubiquitin chain balances ubiquitination and
deubiquitination for determining protein fate. USP7 is one of the best characterized DUBs …