[HTML][HTML] Orthohantavirus pathogenesis and cell tropism

D Noack, M Goeijenbier, CBEM Reusken… - Frontiers in cellular …, 2020 - frontiersin.org
Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection
in specific reservoir species. Although these viruses mainly circulate among rodents …

The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions

J Mustonen, S Mäkelä, T Outinen, O Laine, J Jylhävä… - Antiviral Research, 2013 - Elsevier
Puumala virus (PUUV) causes an acute hemorrhagic fever with renal syndrome (HFRS), a
zoonosis also called nephropathia epidemica (NE). The reservoir host of PUUV is the bank …

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe …

J Klingström, A Smed‐Sörensen… - Journal of internal …, 2019 - Wiley Online Library
Two related hyperinflammatory syndromes are distinguished following infection of humans
with hantaviruses: haemorrhagic fever with renal syndrome (HFRS) seen in Eurasia and …

Increased risk of acute myocardial infarction and stroke during hemorrhagic fever with renal syndrome: a self-controlled case series study

AM Connolly-Andersen, E Hammargren, H Whitaker… - Circulation, 2014 - Am Heart Assoc
Background—We recently observed that cardiovascular causes of death are common in
patients with hemorrhagic fever with renal syndrome (HFRS), which is caused by …

Community acquired severe acute kidney injury caused by hantavirus-induced hemorrhagic fever with renal syndrome has a favorable outcome

TK Outinen, S Mäkelä, J Clement, A Paakkala, I Pörsti… - Nephron, 2015 - karger.com
Background: Puumala hantavirus (PUUV) induces an acute tubulointerstitial nephritis and
acute kidney injury (AKI). Our aim was to evaluate the prognosis of severe AKI associated …

Cardiopulmonary involvement in Puumala hantavirus infection

J Rasmuson, P Lindqvist, K Sörensen… - BMC Infectious …, 2013 - Springer
Background Hantavirus infections cause potentially life-threatening disease in humans
world-wide. Infections with American hantaviruses may lead to hantavirus pulmonary …

Circulating extracellular vesicle tissue factor activity during orthohantavirus infection is associated with intravascular coagulation

CM Schmedes, SP Grover, YM Hisada… - The Journal of …, 2020 - academic.oup.com
Background Puumala orthohantavirus (PUUV) causes hemorrhagic fever with renal
syndrome (HFRS). Patients with HFRS have an activated coagulation system with increased …

Long-term consequences of Puumala hantavirus infection

J Mustonen, A Vaheri, I Pörsti, S Mäkelä - Viruses, 2022 - mdpi.com
Several viral infections are associated with acute and long-term complications. During the
past two years, there have been many reports on post-infectious symptoms of the patients …

Detection of Seoul virus in wild brown rats (Rattus norvegicus) from pig farms in Northern England

EG Murphy, NJ Williams, M Bennett… - Veterinary …, 2019 - Wiley Online Library
Introduction Hantaviruses are maintained by mammalian hosts, such as rodents, and are
shed in their excretions. Clinical disease can occur in humans from spillover infection …

Epidemiological and clinical characteristics of death from hemorrhagic fever with renal syndrome: a meta-analysis

W Lu, L Kuang, Y Hu, J Shi, Q Li, W Tian - Frontiers in Microbiology, 2024 - frontiersin.org
Introduction Hemorrhagic fever with renal syndrome (HFRS) is an acute infectious disease
comprising five stages: fever, hypotension, oliguria, diuresis (polyuria), and convalescence …