Cardiac diseases in the growing population of childhood cancer survivors are of major
concern. Cardiotoxicity as a consequence of anthracyclines and chest radiotherapy …

Survivors of childhood cancer are at risk of anthracycline-induced cardiotoxicity, which might
be prevented by dexrazoxane. However, concerns exist about the safety of dexrazoxane …

Doxorubicin (Dox) is widely used in chemotherapy regimens for several malignant
conditions. Unfortunately, cumulative and irreversible cardiotoxicity of Dox is the most …

G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …

Aims The clinical use of antitumour agent doxorubicin (DOX) is hampered by its dose-
dependent cardiotoxicity. Development of highly efficient and safe adjuvant intervention for …

Background Prior research suggests that cardiovascular autonomic dysfunction might be an
early marker of cardiotoxicity induced by antitumor treatment and act as an early predictor of …

The balance between cardiac sympathetic and parasympathetic activities has been
intricately linked to mitochondrial function, cellular oxidative status, and immunomodulation …

The human gut microbiota is a complex ecosystem that plays a crucial role in promoting the
interaction between the body and its environment. It has been increasingly recognized that …

To evaluate the effect of preventive aerobic exercise training on sympathovagal function,
cardiac function, and DNA repair capacity in a preclinical model of doxorubicin (DOX) …

Cardiotoxicity remains a challenge for the clinical application of doxorubicin. Here, a carrier-
free self-assembled supramolecular named Doxorubicin-Rhein supramolecular (DR Supra) …