Simple Summary Malignant gliomas are of the deadliest, most hard-to-treat cancers, given
their various characteristics of aggression and infiltration as well as the location of growth …

5-Aminolevulinic acid (ALA) is a naturally occurring amino acid synthesized in all nucleated
mammalian cells. As a porphyrin precursor, ALA is metabolized in the heme biosynthetic …

Confining the protein degradation activity of proteolysis-targeting chimera (PROTAC) to
cancer lesions ensures precision treatment. However, it still remains challenging to precisely …

Glioblastomas (GBM) are considered one of the most aggressive tumors of the central
nervous system. The standard treatment for GBM-diagnosed patients implies surgery …

Photodynamic therapy of cancer (PDT) is a therapeutic technique, minimally invasive, which
is currently used to treat cancerous lesions and tumors that have been in the spotlight for its …

Inflammation is activated by diverse triggers that induce the expression of cytokines and
adhesion molecules, which permit a succession of molecules and cells to deliver stimuli and …

Photodynamic therapy (PDT) is a minimally invasive clinical protocol that combines a
nontoxic photosensitizer (PS), appropriate visible light, and molecular oxygen for cancer …

Bromodomain and extraterminal domain (BET) proteins have emerged as therapeutic
targets in multiple cancers, including the most common primary adult brain tumor …

Glioma cells use intermediate levels of reactive oxygen species (ROS) and reactive nitrogen
species (RNS) for growth and invasion, and suppressing these reactive molecules thus may …

The BET family proteins, comprising BRD2, BRD3 and BRD4, represent epigenetic readers
of acetylated histone marks that play pleiotropic roles in the tumorigenesis and growth of …