PDGF/PDGFR axis in the neural systems
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in
several cell types including the brain cells such as neuronal progenitors, neurons …
several cell types including the brain cells such as neuronal progenitors, neurons …
The serotonin 5-HT7 receptors: two decades of research
E Gellynck, K Heyninck, KW Andressen… - Experimental brain …, 2013 - Springer
Like most neurotransmitters, serotonin possesses a simple structure. However, the
pharmacological consequences are more complex and diverse. Serotonin is involved in …
pharmacological consequences are more complex and diverse. Serotonin is involved in …
Modulation of NMDA receptors by G-protein-coupled receptors: role in synaptic transmission, plasticity and beyond
S Lutzu, PE Castillo - Neuroscience, 2021 - Elsevier
NMDA receptors (NMDARs) play a critical role in excitatory synaptic transmission, plasticity
and in several forms of learning and memory. In addition, NMDAR dysfunction is believed to …
and in several forms of learning and memory. In addition, NMDAR dysfunction is believed to …
Pharmacology and Therapeutic Potential of the 5-HT7 Receptor
KM Blattner, DJ Canney, DA Pippin… - ACS Chemical …, 2018 - ACS Publications
It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a
series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first …
series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first …
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview
P Di Pilato, M Niso, W Adriani, E Romano… - Reviews in the …, 2014 - degruyter.com
Abstract The serotonin 7 (5-HT7) receptor was the last serotonin receptor subtype to be
discovered in 1993. This receptor system has been implicated in several central nervous …
discovered in 1993. This receptor system has been implicated in several central nervous …
Insights into the role of platelet-derived growth factors: implications for Parkinson's disease pathogenesis and treatment
D Li, LT Huang, C Zhang, Q Li… - Frontiers in Aging …, 2022 - frontiersin.org
Parkinson's disease (PD), the second most common neurodegenerative disease after
Alzheimer's disease, commonly occurs in the elderly population, causing a significant …
Alzheimer's disease, commonly occurs in the elderly population, causing a significant …
Acute 5-HT7 receptor activation increases NMDA-evoked currents and differentially alters NMDA receptor subunit phosphorylation and trafficking in hippocampal …
MS Vasefi, K Yang, J Li, JS Kruk, JJ Heikkila… - Molecular brain, 2013 - Springer
Background N-methyl-D-aspartate (NMDA) receptors are regulated by several G protein-
coupled receptors (GPCRs) as well as receptor tyrosine kinases. Serotonin (5-HT) type 7 …
coupled receptors (GPCRs) as well as receptor tyrosine kinases. Serotonin (5-HT) type 7 …
5-HT7 receptor activation promotes an increase in TrkB receptor expression and phosphorylation
A Samarajeewa, L Goldemann, MS Vasefi… - Frontiers in behavioral …, 2014 - frontiersin.org
The serotonin (5-HT) type 7 receptor is expressed throughout the CNS including the cortex
and hippocampus. We have previously demonstrated that the application of 5-HT7 receptor …
and hippocampus. We have previously demonstrated that the application of 5-HT7 receptor …
Reactive oxygen species are required for 5-HT-induced transactivation of neuronal platelet-derived growth factor and TrkB receptors, but not for ERK1/2 activation
High concentrations of reactive oxygen species (ROS) induce cellular damage, however at
lower concentrations ROS act as intracellular second messengers. In this study, we …
lower concentrations ROS act as intracellular second messengers. In this study, we …
5‐Hydroxytryptamine type 7 receptor neuroprotection against NMDA‐induced excitotoxicity is PDGFβ receptor dependent
MS Vasefi, JS Kruk, JJ Heikkila… - Journal of …, 2013 - Wiley Online Library
Abstract The serotonin (5‐HT) type 7 receptor is expressed throughout the CNS including
the hippocampus. Long‐term (2–24 h) activation of 5‐HT7 receptors regulates growth factor …
the hippocampus. Long‐term (2–24 h) activation of 5‐HT7 receptors regulates growth factor …