In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …

The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and
inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an …

Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of
anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial …

Radiotherapy is the standard adjuvant treatment for glioma patients; however, the efficacy is
limited by radioresistance. The function of Interleukin-1 receptor associated kinase 1 …

The development of tumor therapeutic resistance is one of the important reasons for the
failure of antitumor therapy. Starting with multiple targets and multiple signaling pathways is …

Interleukin-1 receptor (IL-1R)–associated kinases (IRAKs) are core effectors of Toll-like
receptors (TLRs) and IL-1R in innate immunity. Here, we found that IRAK4 and IRAK1 …

Simple Summary In this review paper, we explore the role of chronic inflammation in the
pathogenesis of prostatic diseases, such as chronic prostatitis, benign prostatic hyperplasia …

Background Metabolic disorder is considered a well-established risk factor for endometrial
carcinoma (EC). However, the mechanism remains unclear. Insulin resistance and …