Genetic architecture, the structure of the mapping from genotype to phenotype, determines
the variational properties of the phenotype and is instrumental in understanding its …

There is reason to suspect that hidden reaction norms (variation that is phenotypically
expressed only after changes in internal or external environmental conditions) may store an …

Dominance is a basic property of inheritance systems describing the link between a diploid
genotype at a single locus and the resulting phenotype. Models for the evolution of …

Deleterious mutations tend to be recessive. Several theories, notably those of Fisher (based
on selection) and Wright (based on metabolism), have been put forward to explain this …

Variability contrasts with variation in that variability describes the potential for variation, not
simply the expressed variation. The power of studying variability lies in creating a …

The genotype–phenotype map (GP map) concept applies to any time point in the ontogeny
of a living system. It is the outcome of very complex dynamics that include environmental …

How epistatic interactions between mutations determine the genetic architecture of fitness is
of central importance in evolution. The study of epistasis is particularly interesting for RNA …

The dominance of deleterious mutations has important consequences for phenomena such
as inbreeding depression, the evolution of diploidy, and levels of natural genetic variation …

In an attempt to understand whether it should be expected that some genes tend to be used
disproportionately often by natural selection, we investigated two related phenomena: the …

Metabolic control analysis has long been used as a systemic model of the genotype–
phenotype (GP) relationship. By considering kinetic parameters and enzyme concentrations …