The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Background Cancer stem cell (CSC)-related chemoresistance leads to poor outcome of the
patients with colorectal cancer (CRC). In this study, we identified the chemoresistance …

Lysosomal degradation of the endoplasmic reticulum (ER) and its components through the
autophagy pathway has emerged as a major regulator of ER proteostasis. Commonly …

The endoplasmic reticulum (ER) produces about 40% of the nucleated cell's proteome. ER
size and content in molecular chaperones increase upon physiologic and pathologic …

Background and aims Sec62 is a membrane protein of the endoplasmic reticulum that
facilitates protein transport. Its role in cancer is increasingly recognised, but remains largely …

Most secreted and membrane proteins are targeted to and translocated across the
endoplasmic reticulum (ER) membrane through the Sec61 protein-conducting channel …

Abstract Background/Purpose: 90-day mortality is a key performance indicator for short-term
perioperative outcome of hepatic resection (HR). Although many preoperative …

The human SEC62 gene is located on chromosome 3q, was characterized as a tumor driver
gene and is found to be overexpressed in an ever-growing number of tumors, particularly …

Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a
frequent amplification of chromosomal region 3q26 that encodes, among others, for the …

Simple Summary Amplification and overexpression of the SEC62 oncogene was reported in
a variety of human cancers and was associated with poor prognosis as well as lymph node …