YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma
RC Chai, YZ Chang, X Chang, B Pang, SY An… - Journal of hematology & …, 2021 - Springer
Background The prognosis for diffuse gliomas is very poor and the mechanism underlying
their malignant progression remains unclear. Here, we aimed to elucidate the role and …
their malignant progression remains unclear. Here, we aimed to elucidate the role and …
[HTML][HTML] LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-κB activity, promoting tumorigenesis
Y Li, X Liu, X Cui, Y Tan, Q Wang, Y Wang, C Xu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Accumulating evidence indicates that long noncoding RNAs (lncRNAs) play
crucial roles in cancer progression; however, only few have been characterized in detail …
crucial roles in cancer progression; however, only few have been characterized in detail …
UBXD proteins: a family of proteins with diverse functions in cancer
K Rezvani - International journal of molecular sciences, 2016 - mdpi.com
The UBXD family is a diverse group of UBX (ubiquitin-regulatory X) domain-containing
proteins in mammalian cells. Members of this family contain a UBX domain typically located …
proteins in mammalian cells. Members of this family contain a UBX domain typically located …
Long non-coding RNA: a potential strategy for the diagnosis and treatment of colorectal cancer
S Chen, Y Fang, L Sun, R He, B He, S Zhang - Frontiers in Oncology, 2021 - frontiersin.org
Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide,
endangers human health. Because the pathological mechanism of CRC is not fully …
endangers human health. Because the pathological mechanism of CRC is not fully …
PTRF/Cavin-1 as a novel RNA-binding protein expedites the NF-κB/PD-L1 axis by stabilizing lncRNA NEAT1, contributing to tumorigenesis and immune evasion in …
K Yi, X Cui, X Liu, Y Wang, J Zhao, S Yang… - Frontiers in …, 2022 - frontiersin.org
Background Immunotherapy, especially checkpoint inhibitors targeting PD-1 or PD-L1, has
revolutionized cancer therapy. However, PD-1/PD-L1 inhibitors have not been investigated …
revolutionized cancer therapy. However, PD-1/PD-L1 inhibitors have not been investigated …
Genome-wide association analysis on host resistance against the rotten body disease in a naturally infected population of large yellow croaker Larimichthys crocea
ZX Zhang, ZY Wang, M Fang, K Ye, X Tang, DL Zhang - Aquaculture, 2022 - Elsevier
Large yellow croaker (Larimichthys crocea) is one of the most important marine fish in
China, representing the highest yield of fish species in marine net cage aquaculture. In …
China, representing the highest yield of fish species in marine net cage aquaculture. In …
[HTML][HTML] LPS-induced acute neuroinflammation, involving interleukin-1 beta signaling, leads to proteomic, cellular, and network-level changes in the prefrontal cortex …
Neuroinflammation induced by peripheral infections leads to various neuropsychiatric
symptoms both in humans and laboratory animals, eg, to the manifestation of sickness …
symptoms both in humans and laboratory animals, eg, to the manifestation of sickness …
Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
Ubiquitin regulatory X (UBX) domain-containing protein 6 (UBXN6) is an essential cofactor
for the activity of the valosin-containing protein p97, an adenosine triphosphatase …
for the activity of the valosin-containing protein p97, an adenosine triphosphatase …
Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing
G Xu, T Li, J Chen, C Li, H Zhao, C Yao, H Dong… - Autophagy, 2018 - Taylor & Francis
Aged and damaged mitochondria can be selectively degraded by specific autophagic
elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to …
elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to …
The CRISPR/Cas9 system targeting EGFR exon 17 abrogates NF-κB activation via epigenetic modulation of UBXN1 in EGFRwt/vIII glioma cells
K Huang, C Yang, Q Wang, Y Li, C Fang, Y Tan, J Wei… - Cancer letters, 2017 - Elsevier
Worldwide, glioblastoma (GBM) is the most lethal and frequent intracranial tumor. Despite
decades of study, the overall survival of GBM patients remains unchanged. epidermal …
decades of study, the overall survival of GBM patients remains unchanged. epidermal …