Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

Background: Neuropsychiatric disorders, such as mood disorders, schizophrenia, and
Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and …

The precursor nerve growth factor (ProNGF) and its receptor p75 neurotrophin receptor
(p75NTR) are upregulated in several brain diseases, including ischemic stroke. The …

Ischemic stroke is one of the major causes of morbidity and mortality worldwide.
Mitochondria play a vital role in the pathological processes of cerebral ischemic injury, but …

It is of particular interest the potential of cannabinoid and angiotensin receptors as targets in
the therapy of Parkinson's disease (PD). While endocannabinoids are neuromodulators that …

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative brain disorder
with significant economic and societal impacts, whereas early AD diagnosis remains a …

Ischemic stroke is one of the major causes of devastating neurological disabilities and
mortality worldwide. Despite extensive research for treatment approaches, there remains …

We and others have previously shown that angiotensin II receptor type 2 receptor (AT2R) is
upregulated in the contralesional hemisphere after stroke in normoglycemic Wistar rats. In …

We and others have previously demonstrated that hypoxia-inducible factor alpha (HIF-1α)
stabilization through diet-induced ketosis plays a vital role during brain ischemic injury. We …

Multi-infarct dementia (MID) is described as a chronic progressive decline in cortical
cognitive function due to the occurrence of multiple infarcts in the cerebral vascularization …