NOX dependent ROS generation and cell metabolism

T Pecchillo Cimmino, R Ammendola… - International Journal of …, 2023 - mdpi.com
Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic
natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS …

[HTML][HTML] The role of NADPH oxidases in infectious and inflammatory diseases

JP Taylor, MT Hubert - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …

The role of lung macrophages in acute respiratory distress syndrome

W Dang, Y Tao, X Xu, H Zhao, L Zou, Y Li - Inflammation Research, 2022 - Springer
Acute respiratory distress syndrome (ARDS) is an acute and diffuse inflammatory lung injury
in a short time, one of the common severe manifestations of the respiratory system that …

The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype

YA Mebratu, S Soni, L Rosas, M Rojas… - … of Physiology-Cell …, 2023 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily
found in the elderly population, and several studies have demonstrated that aging is the …

NADPH oxidases connecting fatty liver disease, insulin resistance and type 2 diabetes: Current knowledge and therapeutic outlook

A Nascè, K Gariani, FR Jornayvaz, I Szanto - Antioxidants, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …

[HTML][HTML] The acute toxicity of mineral Fibres: A systematic in vitro study using different THP-1 macrophage phenotypes

S Mirata, V Almonti, D Di Giuseppe, L Fornasini… - International journal of …, 2022 - mdpi.com
Alveolar macrophages are the first line of defence against detrimental inhaled stimuli. To
date, no comparative data have been obtained on the inflammatory response induced by …

Secretome of hESC-derived MSC-like immune and matrix regulatory cells mitigate pulmonary fibrosis through antioxidant and anti-inflammatory effects

W Hu, J Yang, J Xue, J Ma, S Wu, J Wang, R Xu, J Wei… - Biomedicines, 2023 - mdpi.com
Oxidative stress and inflammation are major drivers in the pathogenesis and progression of
pulmonary fibrosis (PF). The mesenchymal stem cell (MSC) secretome has regenerative …

Formation mechanism of wear-resistant composite film by Span 80-decorated halloysite nanotubes

Y Qin, Y Yang, Y Yang, M Wu, G Yang - Ceramics International, 2022 - Elsevier
Phyllosilicate clay mineral, despite being a high-performance and low-cost lubricant
additive, faces the problems of possible biotoxicity and inconsistent mechanisms. Halloysite …

Transcriptomic Analysis of Macrophage Polarization Protocols: Vitamin D3 or IL-4 and IL-13 Do Not Polarize THP-1 Monocytes into Reliable M2 Macrophages

M Rynikova, P Adamkova, P Hradicka, J Stofilova… - Biomedicines, 2023 - mdpi.com
Two main types of macrophages (Mφ) include inflammatory (M1) and anti-inflammatory (M2)
macrophages. These cells can be obtained in vitro by polarization of monocytic cell lines …

NOX4–TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming

J Pandey, JL Larson-Casey, MH Patil, R Joshi… - Journal of Biological …, 2023 - ASBMB
Pulmonary fibrosis is a progressive lung disease characterized by macrophage activation.
Asbestos-induced expression of nicotinamide adenine dinucleotide phosphate hydrogen …