The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

Since currently available antipsychotic medications predominantly treat hallucinations,
delusions, disorganized thoughts and behavior, and related agitation/aggression, attention …

One of the most widely used guides to prescribing psychiatric medications, the Tenth Edition
of Maudsley Prescribing Guidelines returns with fully updated content and new sections on …

Serotonin type 3 (5-HT3) receptors are pentameric ion channels belonging to the
superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory …

Antipsychotic drugs are often used for the treatment of behavioral and psychological
symptoms of dementia (BPSD), especially psychosis and behavioral disturbances (eg …

The serotonergic system plays an important role in cognitive functions via various 5-HT
receptors. Vortioxetine (Lu AA21004) in development as a novel multimodal antidepressant …

We previously reported that the investigational multimodal antidepressant, vortioxetine,
reversed 5-HT depletion-induced memory deficits while escitalopram and duloxetine did not …

In general, rigorous data on combination therapy in schizophrenia are rare and further
randomized controlled trials, naturalistic trials and head-to-head-trials are necessary. Some …