Context.—The 5th edition of the World Health Organization classification of digestive system
tumors discusses several advancements and developments in understanding the etiology …

HER2-positive gastroesophageal adenocarcinomas (GEAs) are common cancers with high
mortality and the treatment options for advanced/metastatic disease are limited …

Spatial transcriptomics are a collection of genomic technologies that have enabled
transcriptomic profiling on tissues with spatial localization information. Analyzing spatial …

Perioperative chemotherapy with 5‐fluorouracil, leucovorin, oxaliplatin and docetaxel
(FLOT) is a mainstay in the treatment of esophagogastric adenocarcinomas (EGA) …

Background Consensus about the definition and treatment of oligometastatic
oesophagogastric cancer is lacking. Objective To assess the definition and treatment of …

The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric
cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs …

Esophageal cancer (EC) is the deadliest cancer worldwide, with a 92% annual mortality rate
per incidence. Esophageal squamous cell carcinoma (ESCC) and esophageal …

Gastric cancer is an aggressive disease with increasing global incidence in recent years.
Human epidermal growth receptor 2 (HER2) is overexpressed in approximately 10–20% of …

Esophageal adenocarcinoma (EAC) is rapidly increasing in incidence and is associated
with a poor prognosis. Barrett's esophagus (BE) is a known precursor of esophageal …

Esophageal cancer is one of the most lethal cancers worldwide because of its rapid
progression and poor prognosis. Esophageal squamous cell carcinoma (ESCC) and …