Current gaps in sepsis immunology: new opportunities for translational research

I Rubio, MF Osuchowski, M Shankar-Hari… - The Lancet infectious …, 2019 - thelancet.com
Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

Histone deacetylation inhibitors as modulators of regulatory T cells

A von Knethen, U Heinicke, A Weigert… - International journal of …, 2020 - mdpi.com
Regulatory T cells (Tregs) are important mediators of immunological self-tolerance and
homeostasis. Being cluster of differentiation 4+ Forkhead box protein3+ (CD4+ FOXP3+) …

Detection and differentiation of bacterial and fungal infection of neutrophils from peripheral blood using Raman spectroscopy

N Arend, A Pittner, A Ramoji, AS Mondol… - Analytical …, 2020 - ACS Publications
Neutrophils are important cells of the innate immune system and the major leukocyte
subpopulation in blood. They are responsible for recognizing and neutralizing invading …

Imperceptible Supercapacitors with High Area‐Specific Capacitance

J Ge, M Zhu, E Eisner, Y Yin, H Dong… - Small, 2021 - Wiley Online Library
Imperceptible electronics will make next‐generation healthcare and biomedical systems
thinner, lighter, and more flexible. While other components are thoroughly investigated …

Impedimetric microfluidic sensor‐in‐a‐tube for label‐free immune cell analysis

AI Egunov, Z Dou, DD Karnaushenko, F Hebenstreit… - Small, 2021 - Wiley Online Library
Analytical platforms based on impedance spectroscopy are promising for non‐invasive and
label‐free analysis of single cells as well as of their extracellular matrix, being essential to …

[HTML][HTML] Discrimination of immune cell activation using Raman micro-spectroscopy in an in-vitro & ex-vivo model

N Chaudhary, TNQ Nguyen, D Cullen… - … Acta Part A: Molecular …, 2021 - Elsevier
Activation and proliferation of immune cells such as lymphocytes and monocytes are
appropriate inflammatory responses to invading pathogens and are key to overcoming an …

Understanding radiation response and cell cycle variation in brain tumour cells using Raman spectroscopy

IE Hill, M Boyd, K Milligan, CA Jenkins, A Sorensen… - Analyst, 2023 - pubs.rsc.org
Radiation therapy is currently utilised in the treatment of approximately 50% of cancer
patients. A move towards patient tailored radiation therapy would help to improve the …

Leukocyte activation profile assessed by Raman spectroscopy helps diagnosing infection and sepsis

A Ramoji, D Thomas-Rüddel… - Critical care …, 2021 - journals.lww.com
Objectives: Leukocytes are first responders to infection. Their activation state can reveal
information about specific host immune response and identify dysregulation in sepsis. This …

Biochemical analysis of leukocytes after in vitro and in vivo activation with bacterial and fungal pathogens using Raman spectroscopy

A Pistiki, A Ramoji, O Ryabchykov… - International journal of …, 2021 - mdpi.com
Biochemical information from activated leukocytes provide valuable diagnostic information.
In this study, Raman spectroscopy was applied as a label-free analytical technique to …

Application of Raman spectroscopy in the hospital environment

A Pistiki, M Salbreiter, S Sultan… - Translational …, 2022 - Wiley Online Library
The hospital environment is a field with unique microbiological characteristics. Pathogens
evolve and spread in different areas of the hospital affecting patients and staff. In addition, a …