The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …

Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Peptide nucleic acid (PNA) is a synthetic analogue of DNA and RNA, developed more than
a decade ago in which the naturally occurring sugar phosphate backbone has been …

Developed in the early 1990s, peptide nucleic acid (PNA) has emerged as a promising class
of nucleic acid mimic because of its strong binding affinity and sequence selectivity toward …

The two main branches of bionanotechnology involve the self-assembly of either peptides or
DNA. Peptide scaffolds offer chemical versatility, architectural flexibility and structural …

In this paper, we review recent DNA-binding agents that are expected to influence the field
of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure …

Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of
antibiotics, multidrug-resistant bacteria have become a serious threat and a major global …

Nucleic acid biosensors have a growing number of applications in genetics and
biomedicine. This contribution is a critical review of the current state of the art concerning the …

Synthetic antisense oligonucleotides (ASOs) and duplex RNAs (dsRNAs) are an
increasingly successful strategy for drug development. After a slow start, the pace of success …

Since its discovery 12 years ago, aminoethylglycyl peptide nucleic acid (aeg-PNA) has
emerged as one of the successful DNA mimics for potential therapeutic and diagnostic …