In the present article, we review the many facets of mitochondrial dysfunction in amyotrophic
lateral sclerosis (ALS), a fatal neurodegenerative disease due to loss of upper motor …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …

The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the
antioxidative defense whose activity is altered in several chronic diseases, including …

Bioenergetic failure and oxidative stress are common pathological hallmarks of amyotrophic
lateral sclerosis (ALS), but whether these could be targeted effectively for novel therapeutic …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons
(MNs) that causes skeletal muscle paralysis. Familial forms of ALS are linked to mutations in …

Reactive oxygen species (ROS), especially mitochondrial ROS, are postulated to play a
significant role in muscle atrophy. We report a dramatic increase in mitochondrial ROS …

Amyotrophic lateral sclerosis (ALS) is a fatal adult‐onset disease primarily characterized by
upper and lower motor neuron degeneration, muscle wasting and paralysis. It is increasingly …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that affects
the aging population. A progressive loss of motor neurons in the spinal cord and brain leads …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive degeneration of upper and lower motoneurons, leading to muscle weakness …

Background Amyotrophic lateral sclerosis (ALS) is a major cause of neurological disability
and its pathogenesis remains elusive despite a multitude of studies. Although defects of the …