Specialized pro-resolving mediator network: an update on production and actions

N Chiang, CN Serhan - Essays in Biochemistry, 2020 - portlandpress.com
Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …

Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids

R Adili, M Hawley, M Holinstat - Prostaglandins & other lipid mediators, 2018 - Elsevier
Thrombosis is the most common underlying pathology responsible for morbidity and
mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation …

Effects of omega-3 polyunsaturated fatty acids and their metabolites on haemostasis—current perspectives in cardiovascular disease

J Golanski, P Szymanska, M Rozalski - International journal of molecular …, 2021 - mdpi.com
The beneficial effects of long-chain polyunsaturated omega-3 fatty acids (omega-3 PUFAs)
in cardioprotection are widely known and generally accepted. In this literature review, we …

Cyclooxygenases and the cardiovascular system

JA Mitchell, NS Kirkby, B Ahmetaj-Shala… - Pharmacology & …, 2021 - Elsevier
Abstract Cyclooxygenase (COX)-1 and COX-2 are centrally important enzymes within the
cardiovascular system with a range of diverse, sometimes opposing, functions. Through the …

Nutrition, thrombosis, and cardiovascular disease

F Violi, D Pastori, P Pignatelli, R Carnevale - Circulation research, 2020 - Am Heart Assoc
Previous studies reported an inverse association between healthy dietary patterns (such as
Mediterranean diet) and the incidence of cardiovascular events. As the mechanism …

Preventive effect of aspirin eugenol ester on thrombosis in κ-carrageenan-induced rat tail thrombosis model

N Ma, XW Liu, YJ Yang, JY Li, I Mohamed, GR Liu… - PLoS …, 2015 - journals.plos.org
Based on the prodrug principle, aspirin eugenol ester (AEE) was synthesized, which can
reduce the side effects of aspirin and eugenol. As a good candidate for new antithrombotic …

EPA's pleiotropic mechanisms of action: a narrative review

JR Nelson, MJ Budoff, OR Wani, V Le… - Postgraduate …, 2021 - Taylor & Francis
Treatment with icosapent ethyl 4 g/day, a highly purified and stable ethyl ester of
eicosapentaenoic acid (EPA), demonstrated a significant reduction in atherosclerotic …

Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications

B Wu, G Mottola, M Schaller, GR Upchurch Jr… - Molecular aspects of …, 2017 - Elsevier
Acute vascular injury occurs in a number of important clinical contexts, including
spontaneous disease-related events (eg plaque rupture, thrombosis) and therapeutic …

Effects of aspirin on endothelial function and hypertension

MS Dzeshka, A Shantsila, GYH Lip - Current hypertension reports, 2016 - Springer
Purpose of review Endothelial dysfunction is intimately related to the development of various
cardiovascular diseases, including hypertension, and is often used as a target for …

Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice

G Liu, Q Liu, Y Shen, D Kong, Y Gong… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose An appropriate inflammatory response is necessary for cardiac
healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) is an anti‐inflammatory …