Arsenic intoxication: general aspects and chelating agents
Arsenic (As) is widely used in the modern industry, especially in the production of pesticides,
herbicides, wood preservatives, and semiconductors. The sources of As such as …
herbicides, wood preservatives, and semiconductors. The sources of As such as …
Programmed cell death, redox imbalance, and cancer therapeutics
X Dai, D Wang, J Zhang - Apoptosis, 2021 - Springer
Cancer cells are disordered by nature and thus featured by higher internal redox level than
healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain …
healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain …
[HTML][HTML] Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy
Mitochondria play a crucial part in the cell's ability to adapt to the changing
microenvironments and their dysfunction is associated with an extensive array of illnesses …
microenvironments and their dysfunction is associated with an extensive array of illnesses …
Suppression of PI3K/Akt/mTOR/c-Myc/mtp53 positive feedback loop induces cell cycle arrest by dual PI3K/mTOR inhibitor PQR309 in endometrial cancer cell lines
IL Hsin, HP Shen, HY Chang, JL Ko, PH Wang - Cells, 2021 - mdpi.com
Gene mutations in PIK3CA, PIK3R1, KRAS, PTEN, and PPP2R1A commonly detected in
type I endometrial cancer lead to PI3K/Akt/mTOR pathway activation. Bimiralisib (PQR309) …
type I endometrial cancer lead to PI3K/Akt/mTOR pathway activation. Bimiralisib (PQR309) …
A recent development of new therapeutic agents and novel drug targets for cancer treatment
ZD Kifle, M Tadele, E Alemu, T Gedamu… - SAGE open …, 2021 - journals.sagepub.com
Despite recent advances in cancer diagnosis, prevention, detection, as well as
management, the disease is expected to be the top cause of death globally. The …
management, the disease is expected to be the top cause of death globally. The …
CLEFMA induces intrinsic and extrinsic apoptotic pathways through ERK1/2 and p38 signalling in uterine cervical cancer cells
CY Lee, YH Hsiao, PN Chen, HH Wu… - Journal of Cellular …, 2023 - Wiley Online Library
Although concurrent chemoradiotherapy is the cornerstone of treatment for locally advanced
or recurrent uterine cervical cancer, treatment fails at a high rate. Therefore, the …
or recurrent uterine cervical cancer, treatment fails at a high rate. Therefore, the …
Combination treatment with cyclosporin A and arsenic trioxide induce synergistic cell death via non-apoptotic pathway in uterine cervical cancer cells
PJ Wu, IL Hsin, WL Hung, MS Lee, PH Wang… - Chemico-Biological …, 2022 - Elsevier
Cyclosporin A is an immunosuppressive drug with anti-cancer effect. Arsenic trioxide (As 2 O
3), a well-known cancer-inhibiting drug, induced cytotoxicity via apoptosis and autophagy …
3), a well-known cancer-inhibiting drug, induced cytotoxicity via apoptosis and autophagy …
Human prostate cancer cell epithelial-to-mesenchymal transition as a novel target of arsenic trioxide and curcumin therapeutic approach
Abstract Background Arsenic trioxide (As 2 O 3) as an inorganic compound is used to treat
various cancers and other diseases. It has been reported that arsenic trioxide induced …
various cancers and other diseases. It has been reported that arsenic trioxide induced …
Arsenic trioxide induces ferroptosis in neuroblastoma by mediating GPX4 transcriptional inhibition
M Su, X Liu, Y Ma, X Peng, X Xiong… - Clinical and …, 2024 - Wiley Online Library
Neuroblastoma (NB), the most common extracranial solid tumor in childhood, significantly
contributes to cancer‐related mortality, presenting a dearth of efficacious treatment …
contributes to cancer‐related mortality, presenting a dearth of efficacious treatment …
Arsenic trioxide preconditioning attenuates hepatic ischemia-reperfusion injury in mice: Role of ERK/AKT and autophagy
C Wang, H Yu, S Lu, S Ke, Y Xu, Z Feng… - Chinese Medical …, 2025 - journals.lww.com
Background: Arsenic trioxide (ATO) is indicated as a broad-spectrum medicine for a variety
of diseases, including cancer and cardiac disease. While the role of ATO in hepatic …
of diseases, including cancer and cardiac disease. While the role of ATO in hepatic …