[HTML][HTML] A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

AM Allen, MC Neville, S Birtles, V Croset, CD Treiber… - Elife, 2020 - elifesciences.org
The Drosophila ventral nerve cord (VNC) receives and processes descending signals from
the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory …

Synaptic architecture of leg and wing premotor control networks in Drosophila

E Lesser, AW Azevedo, JS Phelps, L Elabbady, A Cook… - Nature, 2024 - nature.com
Animal movement is controlled by motor neurons (MNs), which project out of the central
nervous system to activate muscles. MN activity is coordinated by complex premotor …

Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS

H Lacin, HM Chen, X Long, RH Singer, T Lee… - Elife, 2019 - elifesciences.org
The vast majority of the adult fly ventral nerve cord is composed of 34 hemilineages, which
are clusters of lineally related neurons. Neurons in these hemilineages use one of the three …

G3'MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner

Y Zhang, Q Huang, C Sheng, G Liu, K Zhang, Z Jia… - PLoS …, 2023 - journals.plos.org
Meta-diamides (eg broflanilide) and isoxazolines (eg fluralaner) are novel insecticides that
target the resistant to dieldrin (RDL) subunit of insect γ-aminobutyric acid receptors …

A size principle for recruitment of Drosophila leg motor neurons

AW Azevedo, ES Dickinson, P Gurung… - Elife, 2020 - elifesciences.org
To move the body, the brain must precisely coordinate patterns of activity among diverse
populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and …

Understanding the consequences of repetitive subconcussive head impacts in sport: brain changes and dampened motor control are seen after boxing practice

TG Di Virgilio, M Ietswaart, L Wilson… - Frontiers in human …, 2019 - frontiersin.org
Objectives The potential effects of exposure to repetitive subconcussive head impacts
through routine participation in sport are not understood. To investigate the effects of …

Neuronal mechanisms regulating locomotion in adult Drosophila

SBM Gowda, A Banu, S Hussain… - Journal of …, 2024 - Wiley Online Library
The coordinated action of multiple leg joints and muscles is required even for the simplest
movements. Understanding the neuronal circuits and mechanisms that generate precise …

Static stability predicts the continuum of interleg coordination patterns in Drosophila

NS Szczecinski, T Bockemühl… - Journal of …, 2018 - journals.biologists.com
During walking, insects must coordinate the movements of their six legs for efficient
locomotion. This interleg coordination is speed dependent: fast walking in insects is …

A locomotor assay reveals deficits in heterozygous Parkinson's disease model and proprioceptive mutants in adult Drosophila

A Aggarwal, H Reichert… - Proceedings of the …, 2019 - National Acad Sciences
Severe locomotor impairment is a common phenotype of neurodegenerative disorders such
as Parkinson's disease (PD). Drosophila models of PD, studied for more than a decade …

Piezo-like gene regulates locomotion in Drosophila larvae

Y Hu, Z Wang, T Liu, W Zhang - Cell reports, 2019 - cell.com
To maintain proper locomotive patterns, animals constantly monitor body posture with their
proprioceptive receptors. In Drosophila, the chordotonal organs (Cho) are especially …