Our knowledge of the roles of individual cytochrome P450 (P450) enzymes in drug
metabolism has developed considerably in the past 30 years, and this base has been of …

Coronavirus disease 2019 (COVID-19) has become a new public health crisis threatening
the world. Dysregulated immune responses are the most striking pathophysiological …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Cytochrome P450-dependent ω-hydroxylation is a prototypic metabolic reaction of CYP4
family members that is important for the elimination and bioactivation of not only therapeutic …

Enzymes in the cytochrome P450 4 (CYP4) family are involved in the metabolism of fatty
acids, xenobiotics, therapeutic drugs, and signaling molecules, including eicosanoids …

Consumption of diets rich in fruits and vegetables, which provide some fat-soluble vitamins
and many phytochemicals, is associated with a lower risk of developing certain …

Protein quantification data on drug metabolizing enzymes and transporters (collectively
referred as DMET proteins) in human tissues are useful in predicting interindividual …

Paralytic shellfish toxins (PSTs) are widely distributed neurotoxins, and the PST metabolic
detoxification mechanism in bivalves has received increasing attention. To reveal the effect …

Large interindividual variability has been observed in the metabolism of CYP2C19
substrates in vivo. The study aimed to evaluate sources of this variability in CYP2C19 …

Crohn's disease affects the mucosal layer of the intestine, predominantly ileum and colon
segments, with the potential to affect the expression of intestinal enzymes and transporters …