Better epitope discovery, precision immune engineering, and accelerated vaccine design using immunoinformatics tools

AS De Groot, L Moise, F Terry, AH Gutierrez… - Frontiers in …, 2020 - frontiersin.org
Computational vaccinology includes epitope mapping, antigen selection, and immunogen
design using computational tools. Tools that facilitate the in silico prediction of immune …

Bacterial urease and its role in long-lasting human diseases

I Konieczna, P Zarnowiec, M Kwinkowski… - Current protein and …, 2012 - ingentaconnect.com
Urease is a virulence factor found in various pathogenic bacteria. It is essential in
colonization of a host organism and in maintenance of bacterial cells in tissues. Due to its …

A novel design of a multi-antigenic, multistage and multi-epitope vaccine against Helicobacter pylori: an in silico approach

B Meza, F Ascencio, AP Sierra-Beltrán, J Torres… - Infection, Genetics and …, 2017 - Elsevier
Helicobacter pylori have colonized the gastric mucosa of half of the population worldwide.
This bacterium is classified as a definitive type I carcinogen by the World Health …

H. pylori infection and gastric cancer: state of the art

V Conteduca, D Sansonno… - International …, 2013 - spandidos-publications.com
Gastric cancer (GC) is one of the leading types of cancer worldwide, particularly in East
Asian populations. Helicobacter pylori (HP) infection has been established as a major risk …

[HTML][HTML] Status of vaccine research and development for Helicobacter pylori

P Sutton, JM Boag - Vaccine, 2019 - Elsevier
Gastric adenocarcinoma is globally the third leading cause of death due to malignancy, with
the bulk of this disease burden being suffered by low and middle income countries (LMIC) …

Advances and opportunities in nanoparticle‐and nanomaterial‐based vaccines against bacterial infections

LCW Lin, S Chattopadhyay, JC Lin… - Advanced healthcare …, 2018 - Wiley Online Library
As the dawn of the postantibiotic era we approach, antibacterial vaccines are becoming
increasingly important for managing bacterial infection and reducing the need for antibiotics …

Helicobacter pylori research: historical insights and future directions

KM Fock, DY Graham, P Malfertheiner - … reviews Gastroenterology & …, 2013 - nature.com
Helicobacter pylori leads to chronic gastritis, peptic ulcer disease and gastric cancer. With
increasing issues of antibiotic resistance and changing epidemiology of this pathogen, new …

[HTML][HTML] Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases

A Karkhah, S Ebrahimpour, M Rostamtabar… - Microbiological …, 2019 - Elsevier
Helicobacter pylori (H. pylori) is a bacterial pathogen that resides in more than half of the
human population and has co-evolved with humans for more than 58,000 years. This …

iVAX: An integrated toolkit for the selection and optimization of antigens and the design of epitope-driven vaccines

L Moise, A Gutierrez, F Kibria, R Martin… - Human vaccines & …, 2015 - Taylor & Francis
Computational vaccine design, also known as computational vaccinology, encompasses
epitope mapping, antigen selection and immunogen design using computational tools. The …

Designing an efficient multi-epitope oral vaccine against Helicobacter pylori using immunoinformatics and structural vaccinology approaches

N Nezafat, M Eslami, M Negahdaripour… - Molecular …, 2017 - pubs.rsc.org
Helicobacter pylori is the cunning bacterium that can live in the stomachs of many people
without any symptoms, but gradually can lead to gastric cancer. Due to various obstacles …