Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …

Following studies in the late 1990s that indicated that poor pharmacokinetics and toxicity
were important causes of costly late-stage failures in drug development, it has become …

Background The current health concern to the entire world is the chronic respiratory disease
caused by coronavirus 2 (COVID-19). A specific treatment or proper therapy is still lacking …

Here, we compile the Biopharmaceutics Drug Disposition Classification System (BDDCS)
classification for 927 drugs, which include 30 active metabolites. Of the 897 parent drugs …

The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

Responding to a demonstrated need for scientists to forecast the permeability and
bioavailability (F) properties of compounds before their purchase, synthesis, or advanced …

The COSMO-RS technique is a novel method for predicting the thermodynamic properties of
pure and mixed fluids which are important in many areas, ranging from chemical …

As expenditure on drug development increases exponentially, the overall drug discovery
process requires a sustainable revolution. Since artificial intelligence (AI) is leading the …

Malaria is one of the most significant causes of childhood mortality, but disease control
efforts are threatened by resistance of the Plasmodium parasite to current therapies …

It is generally thought that many drug molecules are transported across biological
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …