Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Toxicity and relapses from the immunochemotherapy used to treat chronic lymphocytic
leukemia (CLL) prompt continued interest in gentle but effective targeted treatment options …

MicroRNAs (miRNAs) are a family of small non-coding RNA molecules of about 20–23
nucleotides in length, which negatively regulate protein-coding genes at post-transcriptional …

Eukaryotic gene expression is a complicated process primarily regulated at the levels of
gene transcription and mRNA translation. The latter involves four main steps: initiation …

Abstract MicroRNAs (miRNAs) are~ 22 nucleotide long, noncoding, endogenous RNA
molecules which exert their functions by base pairing with messenger RNAs (mRNAs) …

Background: Dicer, a ribonuclease, is the key enzyme required for the biogenesis of
microRNAs and small interfering RNAs and is essential for both mammalian development …

This study was performed to assess the biological significance of miR-210 in preeclampsia
and small-for-gestational-age (SGA) pregnancies. Placental miR-210 expression was …

Epithelial ovarian cancer is the most common cause of death from gynecological
malignancies in the Western world. The overall 5-year survival is only 30% due to late …

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …