Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide,
reducing their quality of life and leading to death from respiratory failure within years of …

Background Whether hydrocortisone reduces mortality among patients with septic shock is
unclear. Methods We randomly assigned patients with septic shock who were undergoing …

Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an …

Objective To update the 2008 consensus statements for the diagnosis and management of
critical illness-related corticosteroid insufficiency (CIRCI) in adult and pediatric patients …

Background Septic shock is characterized by dysregulation of the host response to infection,
with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …