Can metformin exert as an active drug on endothelial dysfunction in diabetic subjects?

T Salvatore, PC Pafundi, R Galiero, L Rinaldi… - Biomedicines, 2020 - mdpi.com
Cardiovascular mortality is a major cause of death among in type 2 diabetes (T2DM).
Endothelial dysfunction (ED) is a well-known important risk factor for the development of …

Neuropeptides: Potential neuroprotective agents in ischemic injury

P Saklani, H Khan, S Gupta, A Kaur, TG Singh - Life Sciences, 2022 - Elsevier
Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …

Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase

H Sasaki, H Asanuma, M Fujita, H Takahama… - Circulation, 2009 - Am Heart Assoc
Background—Some studies have shown that metformin activates AMP-activated protein
kinase (AMPK) and has a potent cardioprotective effect against ischemia/reperfusion injury …

Angiopoietin‐2 reverses endothelial cell dysfunction in progeria vasculature

S Vakili, EK Izydore, L Losert, WA Cabral… - Aging …, 2024 - Wiley Online Library
abstract Hutchinson‐Gilford progeria syndrome (HGPS) is a rare premature aging disorder
in children caused by a point mutation in the lamin A gene, resulting in a toxic form of lamin …

Metformin prevents the development of chronic heart failure in the SHHF rat model

A Cittadini, R Napoli, MG Monti, D Rea… - Diabetes, 2012 - Am Diabetes Assoc
Insulin resistance is a recently identified mechanism involved in the pathophysiology of
chronic heart failure (CHF). We investigated the effects of two insulin-sensitizing drugs …

Is erectile dysfunction a marker for cardiovascular disease?

M Kirby, G Jackson, J Betteridge… - International journal of …, 2001 - Wiley Online Library
There is now significant evidence that erectile dysfunction (ED) can be a symptom of
cardiovascular disease, and can act as a marker for disease progression. National Health …

Sexual health inquiry and support is a primary care priority

R Sadovsky, M Nusbaum - The journal of sexual medicine, 2006 - academic.oup.com
ABSTRACT The World Health Organization defines sexual health as “a state of physical,
emotional, mental and sexual well‐being related to sexuality.” This broad definition goes …

Crosstalk between AMPK activation and angiotensin II‐induced hypertrophy in cardiomyocytes: the role of mitochondria

JS Hernández, G Barreto‐Torres… - Journal of cellular …, 2014 - Wiley Online Library
AMP‐kinase (AMPK) activation reduces cardiac hypertrophy, although underlying molecular
mechanisms remain unclear. In this study, we elucidated the anti‐hypertrophic action of …

Crataegus special extract WS® 1442 improves cardiac function and reduces infarct size in a rat model of prolonged coronary ischemia and reperfusion

M Veveris, E Koch, SS Chatterjee - Life Sciences, 2004 - Elsevier
In Germany, hydroalcoholic extracts from hawthorn (Crataegus spp.) leaves with flowers are
approved drugs for the treatment of mild forms of heart insufficiency. Besides cardiotonic …

The effect of low and high-intensity cycling in diesel exhaust on flow-mediated dilation, circulating NOx, endothelin-1 and blood pressure

LV Giles, SJ Tebbutt, C Carlsten, MS Koehle - PLoS One, 2018 - journals.plos.org
Introduction Exposure to air pollution impairs aspects of endothelial function such as flow-
mediated dilation (FMD). Outdoor exercisers are frequently exposed to air pollution, but how …