Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: a review

MP Girard, S Osmanov, OM Assossou, MP Kieny - Vaccine, 2011 - Elsevier
The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …

What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?

GR Campbell, EP Loret - Retrovirology, 2009 - Springer
The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat
is an important factor in viral pathogenesis. In addition to its function as the key trans …

Contribution of nonneutralizing vaccine-elicited antibody activities to improved protective efficacy in rhesus macaques immunized with Tat/Env compared with …

RH Florese, T Demberg, P Xiao, LR Kuller… - The Journal of …, 2009 - journals.aai.org
Previously, chronic-phase protection against SHIV 89.6 P challenge was significantly
greater in macaques primed with replicating adenovirus type 5 host range mutant (Ad5hr) …

IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines

K Banerjee, PJ Klasse, RW Sanders… - AIDS research and …, 2010 - liebertpub.com
We have studied IgG subclass responses to the HIV-1 proteins gp120, gp41, p24, and Tat in
individuals who control their infection without using antiretroviral drugs (HIV-1 controllers; …

The presence of anti-Tat antibodies is predictive of long-term nonprogression to AIDS or severe immunodeficiency: findings in a cohort of HIV-1 seroconverters

G Rezza, V Fiorelli, M Dorrucci… - The Journal of …, 2005 - academic.oup.com
The human immunodeficiency virus (HIV) type 1 Tat protein plays a key role in the life cycle
of the virus and in pathogenesis and is highly conserved among HIV subtypes. On the basis …

Challenges in HIV vaccine research for treatment and prevention

B Ensoli, A Cafaro, P Monini, S Marcotullio… - Frontiers in …, 2014 - frontiersin.org
Many attempts have been made or are ongoing for HIV prevention and HIV cure. Many
successes are in the list, particularly for HIV drugs, recently proposed also for prevention …

An electrochemical label-free DNA impedimetric sensor with AuNP-modified glass fiber/carbonaceous electrode for the detection of HIV-1 DNA

EÇ Yeter, S Şahin, MO Caglayan, Z Üstündağ - Chemical Papers, 2021 - Springer
In this study, a highly sensitive, electrochemical, and label-free DNA impedimetric sensor
was developed using carbonized glass fiber–coal tar pitch (GF–CTP) electrodes supported …

Codon optimization of the tat antigen of human immunodeficiency virus type 1 generates strong immune responses in mice following genetic immunization

L Ramakrishna, KK Anand, KM Mohankumar… - Journal of …, 2004 - Am Soc Microbiol
ABSTRACT DNA vaccines have been successful in eliciting potent immune responses in
mice. Their efficiency, however, is restricted in larger animals. One reason for the limited …

Tat-based therapies as an adjuvant for an HIV-1 functional cure

H Jin, D Li, MH Lin, L Li, D Harrich - Viruses, 2020 - mdpi.com
The human immunodeficiency virus type 1 (HIV) establishes a chronic infection that can be
well controlled, but not cured, by combined antiretroviral therapy (cART). Interventions have …

Candidate HIV-1 Tat vaccine development: from basic science to clinical trials

B Ensoli, V Fiorelli, F Ensoli, A Cafaro, F Titti, S Butto… - Aids, 2006 - journals.lww.com
Over the past 20 years most of the efforts in HIV vaccine development have focused on
sterilizing immunity by targeting the Envelope protein (Env). However, results from …