There are concepts in science that need time to overcome initial disbelief before finally
arriving at the moment when they are embraced by the research community. One of these …

In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

Graft versus host disease (GvHD) is a life-threating complication of allogeneic hematopoietic
stem cell transplantation, which is initially treated with high dose corticosteroids …

Background Graft-versus-host disease (GVHD) is a common fatal complication of
hematopoietic stem cell transplantation (HSCT), where steroids are used as a treatment …

Both mesenchymal stem cells (MSCs) and their corresponding small extracellular vesicles
(sEVs, commonly referred to as exosomes) share similar immunomodulatory properties that …

Accumulating evidence indicates that most primary Wharton's jelly mesenchymal stem cells
(WJ-MSCs) therapeutic potential is due to their paracrine activity, ie, their ability to modulate …

Background For patients with steroid-refractory acute graft-versus-host disease (SR-
aGVHD), effective second-line regimens are urgently needed. Mesenchymal stromal cells …

While cord blood (CB) is primarily utilized in allogeneic hematopoietic cell transplantation
(HCT), the development of novel cell therapy products from CB is a growing and developing …

Hematopoietic stem cells, regulated by their microenvironment (or “niche”), sustain the
production of mature blood and immune cells. Leukemia cells remodel the …

Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of
somatic stem cells for gene and cell therapies. CB and UC can be obtained noninvasively …