Estrogens and androgens in skeletal physiology and pathophysiology

M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …

Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan

AE Stanhewicz, MM Wenner… - American Journal of …, 2018 - journals.physiology.org
Diseases of the cardiovascular system are the leading cause of morbidity and mortality in
men and women in developed countries, and cardiovascular disease (CVD) is becoming …

The impact of sex on gene expression across human tissues

M Oliva, M Muñoz-Aguirre, S Kim-Hellmuth, V Wucher… - Science, 2020 - science.org
INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-
differentiated characteristics. These sex differences have been variously attributed to …

Physiological and molecular sex differences in human skeletal muscle in response to exercise training

S Landen, D Hiam, S Voisin, M Jacques… - The Journal of …, 2023 - Wiley Online Library
Sex differences in exercise physiology, such as substrate metabolism and skeletal muscle
fatigability, stem from inherent biological factors, including endogenous hormones and …

Nuclear receptors: recent drug discovery for cancer therapies

L Zhao, S Zhou, JÅ Gustafsson - Endocrine reviews, 2019 - academic.oup.com
Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications

AK Lucas-Herald, R Alves-Lopes… - Clinical …, 2017 - portlandpress.com
The principle steroidal androgens are testosterone and its metabolite 5α-
dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α …

Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

W Ruksiriwanich, C Khantham, A Muangsanguan… - Plants, 2022 - mdpi.com
Leaves of guava (Psidium guajava L.) have been used in Thai folk medicine without any
supporting evidence as a traditional herbal remedy for hair loss. Androgenetic alopecia …

Deconstructing the sex bias in allergy and autoimmunity: From sex hormones and beyond

S Laffont, JC Guéry - Advances in Immunology, 2019 - Elsevier
Men and women differ in their susceptibility to develop autoimmunity and allergy but also in
their capacity to cope with infections. Mechanisms responsible for this sexual dimorphism …

The immunomodulatory role of the hypothalamus-pituitary-gonad axis: proximate mechanism for reproduction-immune trade offs?

H Segner, BML Verburg-van Kemenade… - Developmental & …, 2017 - Elsevier
The present review discusses the communication between the hypothalamic-pituitary-gonad
(HPG) axis and the immune system of vertebrates, attempting to situate the HPG-immune …

Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer

Z Hou, S Huang, Z Mei, L Chen, J Guo, Y Gao… - Cell Reports …, 2022 - cell.com
Prostate cancer continuously progresses following deprivation of circulating androgens
originating from the testis and adrenal glands, indicating the existence of oncometabolites …