Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review

SHE Kaufmann, C Lange, M Rao, KN Balaji… - The Lancet …, 2014 - thelancet.com
Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …

Host antimicrobial peptides: the promise of new treatment strategies against tuberculosis

J Arranz-Trullén, L Lu, D Pulido, S Bhakta… - Frontiers in …, 2017 - frontiersin.org
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a
global health emergency due to an alarming rise of antimicrobial resistance to its treatment …

Air pollution particulate matter alters antimycobacterial respiratory epithelium innate immunity

CE Rivas-Santiago, S Sarkar, P Cantarella IV… - Infection and …, 2015 - Am Soc Microbiol
Inhalation exposure to indoor air pollutants and cigarette smoke increases the risk of
developing tuberculosis (TB). Whether exposure to ambient air pollution particulate matter …

Oral administration of probiotics increases paneth cells and intestinal antimicrobial activity

SI Cazorla, C Maldonado-Galdeano, R Weill… - Frontiers in …, 2018 - frontiersin.org
The huge amount of intestinal bacteria represents a continuing threat to the intestinal barrier.
To meet this challenge, gut epithelial cells produce antimicrobial peptides (AMP) that act at …

Defensins: the case for their use against mycobacterial infections

H Dong, Y Lv, D Zhao, P Barrow… - Journal of immunology …, 2016 - Wiley Online Library
Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of
the population being infected. Defensins are antibacterial cationic peptides produced by a …

[HTML][HTML] Effects of dust storm events on weekly clinic visits related to pulmonary tuberculosis disease in Minqin, China

Y Wang, R Wang, J Ming, G Liu, T Chen, X Liu… - Atmospheric …, 2016 - Elsevier
Pulmonary tuberculosis (PTB) is a major public health problem in China. Minqin, a
Northwest county of China, has a very high number of annual PTB clinic visits and it is also …

Vitamin D supplementation: a comprehensive review on supplementation for tuberculosis prophylaxis

ER Turnbull, F Drobniewski - Expert review of respiratory medicine, 2015 - Taylor & Francis
Vitamin D plays a large role in the innate immune response against Mycobacterium
tuberculosis (MTB) infection, activation and progression. Likewise, vitamin D deficiency is …

Decoding the Role of Antimicrobial Peptides in the Fight against Mycobacterium tuberculosis

S Saini, S Pal, R Sharma - ACS Infectious Diseases, 2025 - ACS Publications
Tuberculosis (TB), a leading infectious disease caused by the pathogen Mycobacterium
tuberculosis, poses a significant treatment challenge due to its unique characteristics and …

[HTML][HTML] Vitamin D supplementation promotes macrophages' anti-mycobacterial activity in type 2 diabetes mellitus patients with low vitamin D receptor expression

N Lopez-Lopez, I Gonzalez-Curiel… - Microbes and …, 2014 - Elsevier
The increasing number of people with type 2 diabetes (DM2) is alarming and if it is taken
into account that the relative odds of developing tuberculosis in diabetic patients ranges …

Gene therapy based in antimicrobial peptides and proinflammatory cytokine prevents reactivation of experimental latent tuberculosis

O Ramos-Espinosa… - FEMS Pathogens …, 2016 - academic.oup.com
Mycobacterium tuberculosis (Mtb) latent infection can lead to reactivation. The design of new
strategies to prevent it is an important subject. B6D2F1 mice were infected intratracheally …