Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic
anemia, episodic vaso-occlusion, and progressive organ damage. Current management of …

Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell
disease. Symptomatic management and prevention of these events using the fetal …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Painful vaso-occlusive crisis (VOC) remains the most common reason for presenting to the
Emergency Department and hospitalization in patients with sickle cell disease (SCD) …

Sickle cell disease afflicts millions of people worldwide and approximately 100,000
Americans. Complications are myriad and arise as a result of complex pathological …

Background Sickle cell anemia is an inherited blood disorder that is characterized by painful
vaso-occlusive crises, for which there are few treatment options. Platelets mediate …

Sickle cell disease (SCD) is a hypercoagulable state. Patients exhibit increased platelet
activation, high plasma levels of markers of thrombin generation, depletion of natural …

Nucleotides and nucleosides—such as adenosine triphosphate (ATP) and adenosine—are
famous for their intracellular roles as building blocks for the genetic code or cellular energy …

Bioenergetic dysfunction, although central to the pathogenesis of numerous diseases,
remains uncharacterized in many patient populations because of the invasiveness of …