Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

Autoimmune diseases constitute a broad, heterogenous group with many diverse and often
overlapping symptoms. Even so, they are traditionally classified as either systemic …

Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders
and affects autoantibody diversity and disease subgroups. The primary objective of this …

The autoimmune inflammatory myopathy disease spectrum, commonly known as myositis, is
a group of systemic diseases that mainly affect the muscles, skin and lungs. Biomarker …

Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are
associated with specific clinical phenotypes suggesting a pathogenic role of adaptive …

The rheumatic diseases are a diverse group of conditions that can display autoantibody
production, functional immune disturbances and systemic disease manifestations. These …

Idiopathic inflammatory myopathies are a group of rare, autoimmune, diseases typically
involving striate muscle and also variously affecting several other systems or organs, such …

Skeletal muscle has a robust regeneration ability that is impaired by severe injury, disease,
and aging, resulting in a decline in skeletal muscle function. Therefore, improving skeletal …

Objective Idiopathic inflammatory myopathies (myositis, IIMs) are rare, systemic autoimmune
disorders that lead to muscle inflammation, weakness, and extra-muscular manifestations …

Objective The identification of depression primarily relies on the clinical symptoms and
psychiatric evaluation of the patient, in the absence of objective and quantifiable biomarkers …