Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Background Progesterone has been associated with robust positive effects in animal models
of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized …

Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

Progesterone is a well-known steroid hormone, synthesized by ovaries and placenta in
females, and by adrenal glands in both males and females. Several tissues are targets of …

Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …

This article is part of a Special Issue" Hormones & Neurotrauma". Numerous studies aimed
at identifying the role of estrogen on the brain have used the ovariectomized rodent as the …

Sex steroids regulate brain function in both normal and pathological states. Mitochondria are
an essential target of steroids, as demonstrated by the experimental administration of 17β …

The nervous system is a target and a source of steroids. Neuroactive steroids are steroids
that target neurons and glial cells. They include hormonal steroids originated in the …

The mitochondria have a fundamental role in both cellular energy supply and oxidative
stress regulation and are target of the effects of sex steroids, particularly the neuroprotective …