New and emerging approaches to treat psychiatric disorders

KW Scangos, MW State, AH Miller, JT Baker… - Nature medicine, 2023 - nature.com
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Harmonizing the neurobiology and treatment of obsessive-compulsive disorder

WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

Obsessive-compulsive disorder: advances in diagnosis and treatment

ME Hirschtritt, MH Bloch, CA Mathews - Jama, 2017 - jamanetwork.com
Importance Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder associated
with significant impairment and a lifetime prevalence of 1% to 3%; however, it is often …

Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder

NR Provenza, SA Sheth, EM Dastin-van Rijn… - Nature medicine, 2021 - nature.com
Detection of neural signatures related to pathological behavioral states could enable
adaptive deep brain stimulation (DBS), a potential strategy for improving efficacy of DBS for …

Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications

MP Dandekar, AJ Fenoy, AF Carvalho, JC Soares… - Molecular …, 2018 - nature.com
Although deep brain stimulation (DBS) is an established treatment choice for Parkinson's
disease (PD), essential tremor and movement disorders, its effectiveness for the …

Efficacy of deep brain stimulation for treatment-resistant obsessive-compulsive disorder: systematic review and meta-analysis

R Gadot, R Najera, S Hirani, A Anand… - Journal of Neurology …, 2022 - jnnp.bmj.com
Deep brain stimulation (DBS) is an established and growing intervention for treatment-
resistant obsessive-compulsive disorder (TROCD). We assessed current evidence on the …

Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder

JC Baldermann, C Melzer, A Zapf, S Kohl… - Biological …, 2019 - Elsevier
Background Deep brain stimulation for obsessive-compulsive disorder is a rapidly
developing treatment strategy for treatment-refractory patients. Both the exact target and …

Obsessive–compulsive disorder

DJ Stein, DLC Costa, C Lochner, EC Miguel… - Nature reviews Disease …, 2019 - nature.com
Obsessive–compulsive disorder (OCD) is a highly prevalent and chronic condition that is
associated with substantial global disability. OCD is the key example of the 'obsessive …

Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for …

JJ Mahoney III, CA Hanlon, PJ Marshalek… - Journal of the …, 2020 - Elsevier
Given the high prevalence of individuals diagnosed with substance use disorder, along with
the elevated rate of relapse following treatment initiation, investigating novel approaches …