Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

Glucagon is secreted from islet α cells and controls blood levels of glucose in the fasting
state. Impaired glucagon secretion predisposes some patients with type 1 diabetes mellitus …

THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

Abstract Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor,
GLP-1R, is expressed in the brain. Here we show that intracerebroventricular (icv) GLP-1 …

Abstract Glucagon‐like peptide‐1 (GLP‐1) is derived from the peptide precursor pre‐pro‐
glucagon (PPG) by enzymatic cleavage and acts via its receptor, glucagon‐like peptide‐1 …