Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis

C Granziera, J Wuerfel, F Barkhof, M Calabrese… - Brain, 2021 - academic.oup.com
Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

[HTML][HTML] Myelin quantification with MRI: A systematic review of accuracy and reproducibility

CWJ van der Weijden, DV García, RJH Borra… - Neuroimage, 2021 - Elsevier
Objectives Currently, multiple sclerosis is treated with anti-inflammatory therapies, but these
treatments lack efficacy in progressive disease. New treatment strategies aim to repair …

[HTML][HTML] Imaging retinotopic maps in the human brain

BA Wandell, J Winawer - Vision research, 2011 - Elsevier
A quarter-century ago visual neuroscientists had little information about the number and
organization of retinotopic maps in human visual cortex. The advent of functional magnetic …

Comparisons between multi-component myelin water fraction, T1w/T2w ratio, and diffusion tensor imaging measures in healthy human brain structures

MN Uddin, TD Figley, KG Solar, AS Shatil, CR Figley - Scientific reports, 2019 - nature.com
Various MRI techniques, including myelin water imaging, T1w/T2w ratio mapping and
diffusion-based imaging can be used to characterize tissue microstructure. However …

Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

CWJ van der Weijden, E Biondetti, IW Gutmann… - Brain, 2023 - academic.oup.com
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Test–retest reliability and concurrent validity of in vivo myelin content indices: Myelin water fraction and calibrated T1w/T2w image ratio

M Arshad, JA Stanley, N Raz - Human brain mapping, 2017 - Wiley Online Library
In an age‐heterogeneous sample of healthy adults, we examined test–retest reliability (with
and without participant repositioning) of two popular MRI methods of estimating myelin …

One component? Two components? Three? The effect of including a nonexchanging “free” water component in multicomponent driven equilibrium single pulse …

SCL Deoni, L Matthews… - Magnetic resonance in …, 2013 - Wiley Online Library
Quantitative myelin content imaging provides novel and pertinent information related to
underlying pathogenetic mechanisms of myelin‐related disease or disorders arising from …

Motor skill acquisition promotes human brain myelin plasticity

B Lakhani, MR Borich, JN Jackson… - Neural …, 2016 - Wiley Online Library
Experience‐dependent structural changes are widely evident in gray matter. Using diffusion
weighted imaging (DWI), the neuroplastic effect of motor training on white matter in the brain …

Myelin water fraction is transiently reduced after a single mild traumatic brain injury–A prospective cohort study in collegiate hockey players

AD Wright, M Jarrett, I Vavasour, E Shahinfard… - PloS one, 2016 - journals.plos.org
Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and
remain as one of the most poorly understood injuries in the field of neuroscience. Currently …

Feasibility and reproducibility of whole brain myelin water mapping in 4 minutes using fast acquisition with spiral trajectory and adiabatic T2prep (FAST‐T2) at 3T

TD Nguyen, K Deh, E Monohan… - Magnetic resonance …, 2016 - Wiley Online Library
Purpose To develop and measure the reproducibility of 4‐min whole brain myelin water
fraction (MWF) mapping using fast acquisition with spiral trajectory and T2prep (FAST‐T2) …