Currently, 47 million people live with dementia globally, and it is estimated to increase more
than threefold (~ 131 million) by 2050. Alzheimer's disease (AD) is one of the major …

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Metabolic disorders have become among the most serious threats to human health, leading
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …

The potentiation of antibiotics is a promising strategy for combatting antibiotic-
resistant/tolerant bacteria. Herein, we report that a 5-min sublethal heat shock enhances the …

Druggability predictions are important to avoid intractable targets and to focus drug
discovery efforts on sites offering better prospects. However, few druggability prediction tools …

Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged
as the most common form of dementia in the elderly. Several pathological hallmarks have …

In the past two decades, ionic liquids (ILs) have been acknowledged as potentially attractive
“green” and “designer” solvents since their broader chemical space and the tunable nature …

Investigations of genetic diseases such as cystic fibrosis, α‐1‐antitrypsin deficiency,
phenylketonuria, mitochondrial acyl‐CoA dehydrogenase deficiencies, and many others …

The treatment of central nervous system (CNS) malignancies, including brain cancers, is
limited by a number of obstructions, including the blood-brain barrier (BBB), the …