Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

The increasing ageing of our societies is accompanied by a pandemic of obesity and related
cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is …

Epigenetic mechanisms play a pivotal role in the expression of genes and can be influenced
by both the quality and quantity of diet. Dietary compounds such as sulforaphane (SFN) …

Nutrition affects the brain throughout life, with profound implications for cognitive decline and
dementia. These effects are mediated by changes in expression of multiple genes, and …

The lifespan of mice shows genotype, sex and laboratory effects, but little is known about
genotype or sex differences in life expectancy of mouse models of Alzheimer's disease (AD) …

Although preclinical research and observer studies on patients with atrial fibrillation
concluded that direct oral anticoagulants (DOACs) can protect against dementia like …

The pronounced effects of the epigenetic diet (ED) and caloric restriction (CR) have on
epigenetic gene regulation have been documented in many pre-clinical and clinical studies …

Accurately describing the anatomy of individual brains enables interlaboratory
communication of functional and developmental studies and is crucial for possible surgical …

The functions of human brains highly depend on the precise temporal regulation of gene
expression, and the temporal brain transcriptome profile across lifespan has been observed …