Professional phagocytes, such as neutrophils and macrophages, effectively engulf and
eliminate invading microorganisms. To survive this onslaught, pathogens have developed …

Cytosolic inflammasome complexes mediated by a pattern recognition receptor (PRR)
defend against pathogen infection by activating caspase 1. Pyrin, a candidate PRR, can …

Highlights•The pyrin inflammasome is triggered in response to RhoA inactivation.•Bacterial
effectors and toxins that inactivate RhoA vary in mechanism.•Pyrin-induced inflammation …

The success of Staphylococcus aureus as a pathogen is partly attributable to its ability to
thwart host innate immune responses, which includes resisting the antimicrobial functions of …

Burkholderia cenocepacia is an opportunistic pathogen of the cystic fibrosis lung that elicits
a strong inflammatory response. B. cenocepacia employs a type VI secretion system (T6SS) …

Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly
affecting immune activation. A classic response to proinflammatory activation is increased …

The importance of actin dynamics in the activation of the inflammasome is becoming
increasingly apparent. IL-1β, which is activated by the inflammasome, is known to be central …

Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Macrophages and dendritic cells continuously survey their environment in search of foreign
particles and soluble antigens. Such surveillance involves the ongoing extension of actin …

Burkholderia cenocepacia is a Gram‐negative opportunistic pathogen of patients with cystic
fibrosis and chronic granulomatous disease. The bacterium survives intracellularly in …