Parkinson's disease (PD) is an age-related neurodegenerative disorder affecting millions of
people worldwide. The disease is characterized by the progressive loss of dopaminergic …

Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene encoding a core
component of the retromer complex, have recently emerged as a new cause of late-onset …

Whether or how the pathogenic disruptions in endosomal trafficking observed in Alzheimer's
disease (AD) are linked to its anatomical vulnerability remain unknown. Here, we began …

Retromer controls cellular homeostasis through regulating integral membrane protein
sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer …

Parkinson's disease (PD) is a multifactorial disorder involving a complex interplay between a
variety of genetic and environmental factors. In this scenario, mitochondrial impairment and …

Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene represent a cause of late-
onset, autosomal dominant familial Parkinson's disease (PD). A single missense mutation …

Neurotransmission is critically dependent on the number, position, and composition of
receptor proteins on the postsynaptic neuron. Of these, α-amino-3-hydroxy-5-methyl-4 …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been
recognized for over 200 years by its clinically dominant motor system impairment. There are …

Perturbations of the endolysosomal pathway have been suggested to play an important role
in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease …

Alterations in the function of the retromer, a multisubunit protein complex that plays a
specialized role in endosomal sorting, have been linked to Alzheimer's and Parkinson's …