Spermatogenesis, a study of germ cell development, is a long, orderly, and well‐defined
process occurring in seminiferous tubules of the testis. It is a temporal event whereby …

PURPOSE: Activation of the KIT tyrosine kinase by somatic mutation has been documented
in a number of human malignancies, including gastrointestinal stromal tumor (GIST) …

Many adult regenerative cells divide infrequently but have high proliferative capacity. We
developed a strategy to fluorescently label slow-cycling cells in a cell type–specific fashion …

It has been suggested that germline stem cells maintain oogenesis in postnatal mouse
ovaries. Here we show that adult mouse ovaries rapidly generate hundreds of oocytes …

Coordinated regulation of alternative pre-mRNA splicing is essential for germ cell
development. However, the underlying molecular mechanism that controls alternative …

Male germ cells, the repository cells of the genome, comprise several successive
developmental stages starting in the embryo and ending up with the spermatozoon …

Stem cell factor (SCF), the ligand of the c-Kit receptor, is expressed by various structural and
inflammatory cells in the airways. Binding of SCF to c-Kit leads to activation of multiple …

Spermatogonia are the male germ stem cells that continuously produce sperm for the next
generation. Spermatogenesis is a complicated process that proceeds through mitotic phase …

Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators
of ovarian function including the formation of the germ cell precursors, termed primordial …

Alternative pre-mRNA splicing plays important roles in co-transcriptional and post-
transcriptional regulation of gene expression functioned during many developmental …