Exposure to chronic hypobaric hypoxia imposes a significant physiological burden to more
than 80 million humans living above 2500 m throughout the world. Among them, 50 000 live …

Distinct populations of stretch‐sensitive mechanoreceptors attached to myelinated vagal
afferents are found in the heart and adjoining coronary and pulmonary circulations …

Over the last 100 years, high‐altitude researchers have amassed a comprehensive
understanding of the global cardiac responses to acute, prolonged and lifelong hypoxia …

Key points We sought to determine the isolated and combined influence of hypovolaemia
and hypoxic pulmonary vasoconstriction on the decrease in left ventricular (LV) function and …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

New Findings What is the topic of the review? Sympathoexcitation and sympathetic control
of blood pressure at high altitude. What advances does it highlight? Sustained …

Sympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as
persisting in acclimatised lowland populations and with generational exposure in highland …

Background Data regarding the metabolic risk factors clustering on the risk of left ventricular
diastolic dysfunction (LVDD) are lacking among people living at high altitude and under …

High‐altitude cardiac injury (HACI) is one of the common tissue injuries caused by high‐
altitude hypoxia that may be life threatening. Notoginsenoside R1 (NG‐R1), a major saponin …

More than one hundred million people reside worldwide at altitudes in excess of 2500 m
above sea level. In the millions more who sojourn at high altitude for recreational …